The Nidus Center is an incubator laboratory for new technology at the Monsanto Campus in Creve Coeur, Missouri. Designed on a fast-track, and delivered using a design-build methodology, the facility is located on a site where native landscaping is irrigated by rainwater collection cisterns. Energy requirements were reduced through the use of architectural sun screens, specialty glazing, light shelves, skylights, and sloped ceilings that provide appropriate level and quality of light daylighting with efficient direct-indirect lighting fixtures and HVAC systems. Efficient laboratory equipment is enhanced by advanced heat recovery from ventilation systems.